Our research experts
Dr. Jochen Hoffmann
System integration of microfluidics, molecular diagnostics and microsystem technology as enabler for future healthcare products.
“By means of interdisciplinary collaboration by engineers, physicists, chemists, biologists and computer scientists, we create unique innovations for the healthcare sector – “Invented for life” in its truest sense. For example, tailored solutions for future topics which are realized on our lab-on-chip platform.”
Since 2019, in my role as a Senior Expert at Bosch Research, I have been linking the topics of microfluidics and molecular diagnostics with microsystem technology to develop innovative, unconventional solutions. From the outset of my studies, I have been inspired by merging the areas referred to above. In addition to my expert and team leader tasks, I am currently working in close collaboration with the Bosch Healthcare Solutions subsidiary on future topics to develop new, ground-breaking solutions for our Vivalytic platform.
Robert Bosch GmbH
2019Senior Expert in Microfluidics and Molecular Diagnostics
Hans L. Merkle-Stiftung
2013PhD (Eng.): Fabrication of DNA microarrays by digital solid-phase PCR in a next generation sequencing chip
2009Microsystem Technology studies
Robert Bosch GmbH (2019)Analysis Unit for Performing a Polymerase Chain Reaction, Method for Operating such an Analysis Unit, and Method for Producing such an Analysis Unit
- T. Brettschneider, J. Hoffmann
- US 10260091 B2
Robert Bosch GmbH (2018)Microfluidic Device and Method for Analyzing a Sample of Biological Material
- J. Hoffmann
- US 9925537 B2
Robert Bosch GmbH (2018)Sequencing Device and Method for Operating a Sequencing Device
- J. Hoffmann, K. Lemuth
- US 10160999 B2
Albert-Ludwigs-Universität Freiburg (2017)Multiplexed Digital PCR
- J. Hoffmann, G. Roth
- US 9752183 B2
Albert-Ludwigs-Universität Freiburg (2017)Device and Method for Producing a Replicate or Derivative from an Array of Molecules, and Applications thereof
- R. Zengerle, F. von Stetten, G. Roth, J. Hoffmann
- US 9725758 B2
Robert Bosch GmbH (2015)Microfluidic Device for Detecting Cells from a Fluid, Method for Operating such a Device and Method for Producing such a Device
- T. Brettschneider, J. Hoffmann, K. Lemuth
- DE 10 2014 209 193 B4
J. Hoffmann et al. (2012)Solid-phase PCR in a picowell array for immobilizing and arraying 100,000 PCR products to a microscope slide
- J. Hoffmann, M. Trotter, F. von Stetten, R. Zengerle, G. Roth
- Lab on a Chip, 12 (17), pp. 3049-3059
J. Hoffmann et al. (2012)Optical non-contact localization of liquid-gas interfaces on disk during rotation for measuring flow rates and viscosities
- J. Hoffmann, L. Riegger, F. Bundgaard, D. Mark, R. Zengerle, J. Ducrée
- Lab on a Chip, 12 (24), pp. 5231 – 523
J. Hoffmann et al. (2012)Universal protocol for grafting PCR primers onto various Lab-on-a-Chip substrates for solid-phase PCR
- J. Hoffmann, S. Hin, F. von Stetten, R. Zengerle, G. Roth
- RSC Advances, 2 (9), pp. 3885-3889
J. Hoffmann et al. (2010)Pre-storage of liquid reagents in glass ampoules for DNA extraction on a fully integrated lab-on-a-chip cartridge
- J. Hoffmann, D. Mark, S. Lutz, R. Zengerle, F.von Stetten
- Lab on a Chip, 10, pp. 1480-1484
Interview with Dr. Jochen Hoffmann
Senior Expert in Microfluidics and Molecular Diagnostics
Please tell us what fascinates you most about research.
I am particularly attracted to the implementation of ideas which are not only of academic interest but also comply with the criteria of industrial research, such as marketability, user experience, freedom to operate, and strategic fit for Bosch. Realizing ideas which meet both demands represents a double challenge. If they turn into a success, however, their impact and significance are essentially even more far-reaching.
What makes research done at Bosch so special?
The unique opportunity for an idea (of one’s own) to be incorporated in a product. At Bosch Research, this is ensured in a very particular way by numerous experts, excellent technical equipment, and the long-term nature of projects. In addition, a high degree of research freedom is guaranteed by internally established processes and the availability of a wide range of different corporate departments that can assist you. In the area of healthcare in particular, Bosch benefits from close collaboration with renowned top clinical research institutes.
What research topics are you currently working on at Bosch?
I work on miniaturizing and automating processes in the area of clinical diagnostics which have been primarily implemented in central laboratories to date. The results are so-called lab-on-chip systems which deliver accelerated patient-related test results at molecular level. This makes it possible to have a positive influence on topics such as decentralized diagnostics, an aging society and the consequences thereof, as well as increasing costs in the healthcare system.
What are the biggest scientific challenges in your field of research?
Realizing such lab-on-chip technologies is a real challenge as correlations on the micrometer scale in the areas of fluid dynamics, microsystem technology and molecular biology need to be identified and considered. Access to the micro world is tapped by a high degree of openness and flexibility as well as interdisciplinary collaboration in the specialist areas of microsystem technology, physics, chemistry, bioinformatics, molecular biology, and medicine.
How do the results of your research become part of solutions "Invented for life"?
Our Vivalytic-platform swiftly and reliably detects infectious diseases and improves thereby, the life quality of patients decisively – this is technology “Invented for life” at its best.