Tanja Maucher, Dipl.-Ing.
Automated molecular diagnostics – a tool for quick medical assessment at the point of need
"Science forces us to give up the belief in simple causalities." – Friedrich Nietzsche
I am a research engineer in the “Life Science” working group with a focus on the area of molecular diagnostics. I mainly focus on the characterization & integration of biological analysis and proof processes into the Vivalytic lab-on-a-chip system, which was introduced onto the automated laboratory diagnostics market by the Bosch Healthcare Solutions GmbH (BHCS) division in spring 2020. In close dialog with BHCS, in the strategic Healthcare Solutions portfolio we enable tapping into new market segments by making innovative clinical sample materials processable and new biomarkers in Vivalytic LoC cartridges detectable.
In addition, owing to my microbiological background, I have responsibility at the Renningen location for infection protection and the safe operation of the Life Science laboratory (Biosafety Level 2).
Before Bosch, I worked in the field of “interfacial biology,” in which we researched the targeted use but also the elimination of biofilms. New assessment methods were developed here, adapted to the respective issue, for processes where established standard methods reach their limits.
- Research Engineer with focus on biological assay characterization & integration in Lab-on-Chip diagnostic devices, Bosch Research
- Research in the field of water monitoring with biosensors, University of Stuttgart
- Research Engineer in the area of interfacial microbiology, Fraunhofer IGB
V. Cimalla et al. (2015)Control of drinking water by linking biosensors with physicochemical methods
- V. Cimalla, S. Hugger, F. Fuchs, J. Anzt, M. Bitterling, N. Yang, C. Kohl, T. Maucher, I. Mühlemeier, A. Burger-Kentischer, I. Trick
C. Weber et al. (2014)Enzyme-functionalized biomimetic apatites: concept and perspectives in view of innovative medical approaches
- C. Weber, M. Mueller, N. Vandecandelaere, I. Trick, A. Burger-Kentischer, T. Maucher, C. Drouet
T. Maucher et al. (2011)Assembly of Standardized Test Specimen for Microbial Quantification of Plasma Sterilization Processes of Fine PTFE Tubes as Used in Thermo Sensitive Medical Devices Like Flexible Endoscopes
- T. Maucher, U. Schnabel, W. Volkwein, J. Köhnlein, J. Winter, K.-D. Weltmann, I. Trick, C. Oehr
U. Schnabel et al. (2012)Multicentre Trials for Decontamination of fine-lumen PTFE Tubes loaded with Bacterial Endospores by Low and Atmospheric Pressure Plasma
- U. Schnabel, T. Maucher, J. Köhnlein, W. Volkwein, R. Niquet, I. Trick, M. Stieber, M. Müller, H.-P. Werner, J. Ehlbeck, C. Oehr, K.-D. Weltmann
Interview with Tanja Maucher, Dipl.-Ing.
Graduate Engineer in Environmental and Process Engineering (consolidation Biotechnology)
Please tell us what fascinates you most about research.
What fascinates me most about research is to be able to answer complex questions or solve problems using systematic approaches. Slowly but surely revealing and understanding initially unclear correlations. This motivates me and it is what I enjoy about science.
What makes research done at Bosch so special?
In my research area, medical laboratory diagnostics, experts from the areas of (molecular, cell, micro)biology, (bio)chemistry, physics, microsystems technology, fluid simulation, electronics, mechanical engineering, and plastics engineering work together to make diagnostics available more quickly and to more people. This enables interaction between the different scientific disciplines and promotes cooperation. Here, biologists program fluidic flow sequences for automated laboratory diagnostics and physicians explain the polymerase chain reaction. You will only find this at Bosch.
What research topics are you currently working on at Bosch?
I am currently supporting various projects within the strategic Healthcare solutions portfolio in order to fill the Vivalytic platform product pipeline and to support the BHCS division in its development towards becoming a leading provider of point-of-care (PoC) diagnostic solutions.
What are the biggest scientific challenges in your field of research?
In a miniaturized and fully automated system of medical laboratory diagnostics, a large number of parameters are to be taken into consideration to ensure sensitivity, specificity, and robustness. Microfluidics occupies a position of key importance here by allowing biological, (bio)chemical, optical, and mechanical functions to interact intelligently with each other on the smallest space. This requires a detailed understanding of all the individual functions and their interaction, where biology often tips the scales.
How do the results of your research become part of solutions "Invented for life"?
During the COVID-19 pandemic, Bosch is showing with its Vivalytic platform how invented for life can have a direct, positive influence on people’s lives. The automated proof of SARS-CoV-2 in a closed system allows for diagnosis even far away from fully equipped laboratories and therefore makes it easier to fight the pandemic at every point of need.