Our research experts
Young Shik Shin, Ph.D.
Technologies for medical diagnostics – invented for life
“We redesign common practices in medical diagnostics through new inventions, especially by combining electronics, chemistry, and biology.”
I am an engineer with a broad background from mechanical engineering to medical diagnostics. Currently, I am a senior research scientist in the bioelectronics team. Our team is developing new technologies for next-generation medical diagnostics, especially for point-of-care applications. Our vision is to revolutionize healthcare by combining Bosch competencies such as MEMS sensors, circuit design, wireless communication, and biochemistry.
University of California (LA)
Application of single-cell proteomics technology to the clinic
California Institute of Technology
Ph.D. in Bioengineering: Development of nano/micro technologies for biosensors
Seoul National University
Transition from mechanical engineering to biomedical engineering
N. Kravchenko-Balasha et al. (2016)Intercellular signaling through secreted proteins induces free-energy gradient-directed cell movement
- N. Kravchenko-Balasha, Y. S. Shin, A. Sutherland, R. D. Levine, J. R. Heath
- Proceedings of the National Academy of Sciences of the Unites States of America, vol. 113, issue 20, p. 5520–5525
W. Wei et al. (2016)Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma
- W. Wei, Y. S. Shin, M. Xue, T. Matsutani, K. Masui, H. Yang, S. Ikegami, Y. Gu, K. Herrmann, D. Johnson, X. Ding, K. Hwang, J. Kim, J. Zhou, Y. Su, X. Li, B. Bonetti, R. Chopra, C. D. James, W. K. Cavenee, T. F. Cloughesy, P. S. Mischel, J. R. Heath, B. Gini
- Cancer Cell, vol. 29, issue 4, p. 563-573
Y. S. Shin et al. (2015)Quantitative assessments of glycolysis from single cells
- Y. S. Shin, J. Kim, D. Johnson, A. A. Dooraghi, W. X. Mai, L. Ta, A. F. Chatziioannou, M. E. Phelps, D. A. Nathanson, J. R. Heath
- TECHNOLOGY, vol. 3, issue 4, p. 172-178
Y. S. Shin et al. (2012)A microfluidic-based bubble generation platform enables analysis of physical property change in phospholipid surfactant layers by interfacial ozone reaction
- Y. S. Shin, T. S. Choi, H. Kim, J. L. Beauchamp, J. R. Heath, H. I. Kim
- Biophysical Journal, issue 24, p. 2378-2386
Y. S. Shin et al. (2011)Protein Signaling Networks from Single Cell Fluctuations and Information Theory Profiling
- Y. S. Shin, F. Remacle, R. Fan, K. Hwang, W. Wei, H. Ahmad, R. D. Levine, J. R. Heath
- Biophysical Journal, vol. 100, issue 10, p. 2378-2386
Y. S. Shin et al. (2010)Chemistries for Patterning Robust DNA MicroBarcodes Enable Multiplex Assays of Cytoplasm Proteins from Single Cancer Cells
- Y. S. Shin, H. Ahmad, Q. Shi, H. Kim, T. A. Pascal, R. Fan, W. A. Goddard III, J. R. Heath
- ChemPhysChem, vol. 11, issue 14, p. 3063-3069
Y. L. Bunimovich et al. (2006)Quantitative Real-Time Measurements of DNA Hybridization with Alkylated Nonoxidized Silicon Nanowires in Electrolyte Solution
- Y. L. Bunimovich, Y. S. Shin, W. Yeo, M. Amori, G. Kwong, J. R. Heath
- Journal of the American Chemical Society, vol. 128, issue 50, p. 16323-16331
C. Lee et al. (2005)Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics
- C. Lee, G. Sui, A. Elizarov, C. J. Shu, Y. S. Shin, A. N. Dooley, J. Huang, A. Daridon, P. Wyatt, D. Stout, H. C. Kolb, O. N. Witte, N. Satyamurthy, J. R. Heath, M. E. Phelps, S. R. Quake, H. Tseng
- Science, vol. 310, issue 5755, p. 1793 – 1796
Y. S. Shin et al. (2004)Electrotransfection of Mammalian Cells Using Microchannel-Type Electroporation Chip
- Y. S. Shin, K. Cho, J. K. Kim, S. H. Lim, C. H. Park, K. B. Lee, Y. Park, C. Chung, D. Han, J. K. Chang
- Analytical Chemistry, vol. 76, issue 23, p. 7045-7052
Y. S. Shin et al. (2003)PDMS-based micro PCR chip with Parylene coating
- Y. S. Shin, K. Cho, S. H. Lim, S. Chung, S. Park, C. Chung, D. Han, J. K. Chang
- Journal of Micromechanics and Microengineering, vol. 13, issue 5, p. 768-774
Interview with Young Shik Shin, Ph.D.
Lead Research Scientist for Medical Diagnostic Technologies
Please tell us what fascinates you most about research.
Influencing people’s real lives through my inventions has been the major motivation of my research. The outcome of my master’s thesis work was commercialized by a startup company spun out of my former research group and now you can find the product in the market. This experience boosted my passion toward practical engineering through which you can help people by making new technologies available. My research for my Ph.D. and during my time at UCLA also focused on practical technology developments, some of which are used by startup companies as well.
What makes research done at Bosch so special?
I believe that Bosch has a huge potential in the healthcare field. It is not just because of the motto, “Invented for Life”. Bosch has competencies in core engineering fields such as sensors, actuators, and even packaging which are very relevant to medical device development. Medical devices also require a high level of regulatory practice for production and development processes. Since the automobile industry also has high standards for quality control, it is not so difficult for us to achieve the standards required for medical devices. The Bosch hospital is another great asset we have. We can get direct input on various clinical cases. All of these indicate, I believe, that what we develop here has the preconceived momentum to become a medical test product, and that is something very special for the healthcare industry.
What research topics are you currently working on at Bosch?
The basis of the research in our team is the synergistic combination of electronics with biology. Circuit design and electronics is the core strength of our department, and we want to incorporate this into the technologies for biology. I am currently developing biosensors targeting proteins and DNA. These tests are widely used in the clinic as well as in fundamental biology research. The role of electronics, however, is very limited for such tests. I want to bring more electronics to diagnostics, which can provide more accurate and faster test results to doctors and patients.
What are the biggest scientific challenges in your field of research?
I think it is the gap. There are many different kinds of gaps to overcome in the medical diagnostics field. The first gap is between clinicians and engineers. Engineers need to understand how medical doctors use technologies in their practice and what the actual needs are, which is not straightforward to learn in many cases. Another gap is between available cutting-edge technologies and currently used ones. Medicine is a very conservative field and it is difficult to expect a very fast adoption of new things. A new medical device has to gain FDA approval to get into the market and it usually takes several years at least. This widens the gap even further. Therefore, minimizing those gaps are our challenges in order to develop technologies that have a higher potential impact in the clinic yet a lower barrier for commercialization.
How do the results of your research become part of solutions "Invented for life"?
We are developing technologies for healthcare. I think that simply answers the question.